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Analysis of the Relationship between Cigarette Smoking and Serum Dioxin and Fasting Blood Glucose Levels
J Korean Soc Res Nicotine Tob 2024; 15(4): 126-134
Published online December 30, 2024
© 2024 The Korean Society for Research on Nicotine and Tobacco.

Do Yeon Lim1, Sun Ha Jee1,2*

1Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, 2Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea
Correspondence to: *지선하
연세대학교 보건대학원
역학건강증진학과
E-mail: jsunha@yuhs.ac
Received July 17, 2024; Revised December 15, 2024; Accepted December 17, 2024.
This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, dis-tribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
Background: Smoking, recognized globally as a serious public health problem, is a major risk factor for various diseases and increased mortality. Particularly, cigarette smoking reportedly increases the serum dioxin levels through exposure to environmental toxic substances, which is associated with poor blood glucose control and an increased risk of developing diabetes. However, studies on the relationship between smoking and blood dioxin and fasting blood levels are lacking.
Methods: This study targeted 350 people who visited the hospital for health checkups. They completed a self-report questionnaire, and blood sampling was performed for measuring the serum dioxin levels. The collected data were examined through linear regression and mediation analyses. Fifty bootstrapping analyses were performed for each model.
Results: Among the participants who had smoked in the past and who smoked for <20 years, the fasting blood glucose level increased by 8.86 mg/dL (P=0.0317), whereas those who smoked for ≥20 years, it increased by 13.94 mg/dL (P=0.0025). In the all-participant analysis, the fasting blood glucose level increased by 0.39 mg/dL for each unit increase in the plasma dioxin level (P=0.0211).
Conclusion: Smoking has a direct effect on the blood glucose level, but the indirect effect through dioxin appears to be minimal. However, the present study is limited, as the temporal link cannot be established due to the limitations of a cross-sectional study. Therefore, it is necessary to conduct a prospective cohort study in the future.
Keywords : Smoking; Plasma dioxin; Serum glucose; Mediation; Cross sectional
References
  1. GBD 2019 Chewing Tobacco Collaborators. Spatial, temporal, and demographic patterns in prevalence of chewing tobacco use in 204 countries and territories, 1990-2019: a systematic analysis from the Global Burden of Disease Study 2019. Lancet Public Health. 2021 Jul;6(7):e482-e499. doi: 10.1016/S2468-2667(21)00065-7. Epub 2021 May 28. Erratum in: Lancet Public Health. 2021;6:e449. PMID: 34051920; PMCID: PMC8251505.
  2. World Health Organization (WHO). World No Tobacco Day 2020: Tobacco. Fact Sheet [Internet]. Geneva: WHO; 2020 [cited 2020 May 31].
  3. Moon HJ, Lim JE, Jee SH. Association between serum concentrations of persistent organic pollutants and smoking in Koreans: A crosssectional study. J Epidemiol. 2017;27:63-8. doi: 10.1016/j.je.2016. 09.006. Epub 2016 Nov 15. PMID: 28142013; PMCID: PMC5328728.
    Pubmed KoreaMed CrossRef
  4. Lee DH, Lind L, Jacobs DR Jr, Salihovic S, van Bavel B, Lind PM. Does mortality risk of cigarette smoking depend on serum concentrations of persistent organic pollutants? Prospective investigation of the vasculature in Uppsala seniors (PIVUS) study. PLoS One. 2014;9: e95937. doi: 10.1371/journal.pone.0095937. PMID: 24828407; PMCID: PMC4020745.
    Pubmed KoreaMed CrossRef
  5. Chang CJ, Terrell ML, Marcus M, Marder ME, Panuwet P, Ryan PB, Pearson M, Barton H, Barr DB. Serum concentrations of polybrominated biphenyls (PBBs), polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) in the Michigan PBB Registry 40 years after the PBB contamination incident. Environ Int. 2020 Apr;137:105526. doi: 10.1016/j.envint.2020.105526. Epub 2020 Feb 18. PMID: 32062441; PMCID: PMC7201813.
    Pubmed KoreaMed CrossRef
  6. Lee DH, Lee IK, Porta M, Steffes M, Jacobs DR Jr. Relationship between serum concentrations of persistent organic pollutants and the prevalence of metabolic syndrome among non-diabetic adults: results from the National Health and Nutrition Examination Survey 1999-2002. Diabetologia. 2007;50:1841-51. doi: 10.1007/s00125-007-0755-4. Epub 2007 Jul 12. PMID: 17624515.
    Pubmed CrossRef
  7. Sia HK, Kor CT, Tu ST, Liao PY, Wang JY. Association between smoking and glycemic control in men with newly diagnosed type 2 diabetes: a retrospective matched cohort study. Ann Med. 2022;54:1385-94. doi: 10.1080/07853890.2022.2075559. PMID: 35576130; PMCID: PMC9126565.
    Pubmed KoreaMed CrossRef
  8. Park SE, Seo MH, Cho JH, Kwon H, Kim YH, Han KD, Jung JH, Park YG, Rhee EJ, Lee WY. Dose-Dependent Effect of Smoking on Risk of Diabetes Remains after Smoking Cessation: A Nationwide Population-Based Cohort Study in Korea. Diabetes Metab J. 2021;45:539-46. doi: 10.4093/dmj.2020.0061. Epub 2021 Mar 4. PMID: 33662197; PMCID: PMC8369207.
    Pubmed KoreaMed CrossRef
  9. Jeong SH, Joo HJ, Kwon J, Park EC. Association Between Smoking Behavior and Insulin Resistance Using Triglyceride-Glucose Index Among South Korean Adults. J Clin Endocrinol Metab. 2021;106: e4531-e4541. doi: 10.1210/clinem/dgab399. Erratum in: J Clin Endocrinol Metab. 2022;107:e2219. PMID: 34160623.
    Pubmed CrossRef
  10. Lee SH, Lim YW, Kang YS, Jung KJ, Jee SH. The Association between Blood Concentrations of PCDD/DFs, DL-PCBs and the Risk of Type 2 Diabetes Mellitus and Thyroid Cancer in South Korea. Int J Environ Res Public Health. 2022;19:8745. doi: 10.3390/ijerph19148745. PMID: 35886598; PMCID: PMC9320419.
    Pubmed KoreaMed CrossRef
  11. The jamovi project (2023). jamovi. (Version 2.4) [Computer Software]. Retrieved from https://www.jamovi.org.
  12. R Core Team (2022). R: A Language and environment for statistical computing. (Version 4.1) [Computer software]. Retrieved from https://cran.r-project.org. (R packages retrieved from CRAN snapshot 2023-04-07).
  13. Chi X, Liu X, Li C, Jiao W. The impact of chronic disease diagnoses on smoking behavior change and maintenance: Evidence from China. Tob Induc Dis. 2024 Jan 23;22. doi: 10.18332/tid/176947. PMID: 38264188; PMCID: PMC10804861.
    Pubmed KoreaMed CrossRef
  14. Zhang P, Jiang H, Chen W. Health shocks and changes in preventive behaviors: Results from the China Health and Retirement Longitudinal Study. Front Public Health. 2022;10:954700. doi: 10.3389/fpubh. 2022.954700. PMID: 35968418; PMCID: PMC9363769.
    Pubmed KoreaMed CrossRef
  15. Puleo GE, Borger T, Bowling WR, Burris JL. The State of the Science on Cancer Diagnosis as a “Teachable Moment” for Smoking Cessation: A Scoping Review. Nicotine Tob Res. 2022;24:160-8. doi: 10.1093/ntr/ntab139. PMID: 34212198; PMCID: PMC8807170.
    Pubmed KoreaMed CrossRef
  16. Keenan PS. Smoking and weight change after new health diagnoses in older adults. Arch Intern Med. 2009;169:237-42. doi: 10.1001/archinternmed.2008.557. PMID: 19204214; PMCID: PMC3752594.
    Pubmed KoreaMed CrossRef
  17. Huang CY, Wu CL, Yang YC, Chang JW, Kuo YC, Cheng YY, Wu JS, Lee CC, Guo HR. Association between Dioxin and Diabetes Mellitus in an Endemic Area of Exposure in Taiwan: A Population-Based Study. Medicine (Baltimore). 2015;94:e1730. doi: 10.1097/MD.0000000000001730. PMID: 26496286; PMCID: PMC4620805.
    Pubmed KoreaMed CrossRef
  18. Brown VJ. Dioxin Exposure and Cardiovascular Disease: An Analysis of Association. Environ Health Perspect. 2008;116:A491. PMCID: PMC2592298.
    CrossRef
  19. Nishijo M. Dioxin and Dioxin-like Compounds and Human Health. Toxics. 2023;11:512. doi: 10.3390/toxics11060512. PMID: 37368612; PMCID: PMC10304564.
    Pubmed KoreaMed CrossRef
  20. Sofo V, Götte M, Laganà AS, Salmeri FM, Triolo O, Sturlese E, Retto G, Alfa M, Granese R, Abrão MS. Correlation between dioxin and endometriosis: an epigenetic route to unravel the pathogenesis of the disease. Arch Gynecol Obstet. 2015;292:973-86. doi: 10.1007/s00404-015-3739-5. Epub 2015 Apr 29. PMID: 25920525.
    Pubmed CrossRef
  21. Hassan HF, Elaridi J, Kharma JA, Abiad MG, Bassil M. Persistent Organic Pollutants in Human Milk: Exposure Levels and Determinants among Lactating Mothers in Lebanon. J Food Prot. 2022;85:384-9. doi: 10.4315/JFP-21-325. PMID: 34762730.
    Pubmed CrossRef
  22. EFSA Panel on Contaminants in the Food Chain (CONTAM); Knutsen HK, Alexander J, Barregård L, Bignami M, Brüschweiler B, Ceccatelli S, Cottrill B, Dinovi M, Edler L, Grasl-Kraupp B, Hogstrand C, Nebbia CS, Oswald IP, Petersen A, Rose M, Roudot AC, Schwerdtle T, Vleminckx C, Vollmer G, Wallace H, Fürst P, Håkansson H, Halldorsson T, Lundebye AK, Pohjanvirta R, Rylander L, Smith A, van Loveren H, Waalkens-Berendsen I, Zeilmaker M, Binaglia M, Gómez Ruiz JÁ, Horváth Z, Christoph E, Ciccolallo L, Ramos Bordajandi L, Steinkellner H, Hoogenboom LR. Risk for animal and human health related to the presence of dioxins and dioxin-like PCBs in feed and food. EFSA J. 2018;16:e05333. doi: 10.2903/j.efsa.2018.5333. PMID: 32625737; PMCID: PMC7009407.
    Pubmed CrossRef
  23. Sultana R, Nessa A, Begum S, Yesmin F, Khanam A, Nasreen S, Asrin M. Fasting Serum Glucose Level in Male Cigarette Smoker. Mymensingh Med J. 2019;28:808-10. PMID: 31599244.
  24. Haj Mouhamed D, Ezzaher A, Neffati F, Douki W, Gaha L, Najjar MF. Effect of cigarette smoking on insulin resistance risk. Ann Cardiol Angeiol (Paris). 2016;65:21-5. doi: 10.1016/j.ancard.2014.12.001. Epub 2015 Jan 16. PMID: 25620470.
    Pubmed CrossRef