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Respiratory Health Effects of E-Cigarettes
J Korean Soc Res Nicotine Tob 2021; 12(2): 37-42
Published online December 15, 2021
© 2021 The Korean Society for Research on Nicotine and Tobacco.

Dong Won Park*, Ho Joo Yoon, Jang Won Sohn

Division of Pulmonary Medicine and Allergy, Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea
Correspondence to: 박동원
한양대학교 의과대학 내과학교실 호흡기알레르기내과
E-mail: dongwonpark@hanyang.ac.kr
ORCID: https://orcid.org/0000-0002-4538-6045
Received December 9, 2021; Revised December 15, 2021; Accepted December 16, 2021.
This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, dis-tribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
Electronic cigarettes (e-cigarettes) are battery-powered nicotine delivery systems that generate an inhalable aerosol containing nicotine, flavors, propylene glycol, and vegetable glycerin. Even though there is little evidence on e-cigarettes’ safety and effectiveness as a smoking cessation aid, e-cigarette usage has drastically increased globally. E-cigarettes reached the market without extensive preclinical toxicology testing or long-term safety trials that would be required of conventional therapeutics or medical devices. In August 2019, several cases of e-cigarette or vaping use-associated lung injury have been reported in the United States and this outbreak reminded the potential health risks of e-cigarette. Herein, we review the evidence on the effects of e-cigarettes on respiratory health.
Keywords : Electronic cigarettes; Toxicology; EVALI; Smoking cessation
References
  1. Eissenberg T, Bhatnagar A, Chapman S, Jordt SE, Shihadeh A, Soule EK. Invalidity of an Oft-Cited Estimate of the Relative Harms of Electronic Cigarettes. Am J Public Health 2020; 110: 161-2.
    Pubmed KoreaMed CrossRef
  2. Marynak K, Holmes CB, King BA, Promoff G, Bunnell R, McAfee T, et al. State laws prohibiting sales to minors and indoor use of electronic nicotine delivery systems--United States, November 2014. MMWR Morb Mortal Wkly Rep 2014; 63: 1145-50.
  3. Cooke A, Fergeson J, Bulkhi A, Casale TB. The Electronic Cigarette: The Good, the Bad, and the Ugly. J Allergy Clin Immunol Pract 2015; 3: 498-505.
    Pubmed CrossRef
  4. Lee YH, Chiang T, Kwon E, Baik S, Chang YC. Trends and sociodemographic factors of e-cigarette use among adult daily smokers in South Korea. Int J Health Plann Manage 2020; 35: 960-9.
    Pubmed CrossRef
  5. Bao W, Xu G, Lu J, Snetselaar LG, Wallace RB. Changes in Electronic Cigarette Use Among Adults in the United States, 2014-2016. JAMA 2018; 319: 2039-41.
    Pubmed KoreaMed CrossRef
  6. Filippidis FT, Laverty AA, Gerovasili V, Vardavas CI. Two-year trends and predictors of e-cigarette use in 27 European Union member states. Tob Control 2017; 26: 98-104.
    Pubmed KoreaMed CrossRef
  7. Bowler RP, Hansel NN, Jacobson S, Graham Barr R, Make BJ, Han MK, et al. Electronic Cigarette Use in US Adults at Risk for or with COPD: Analysis from Two Observational Cohorts. J Gen Intern Med 2017; 32: 1315-22.
    Pubmed KoreaMed CrossRef
  8. Layden JE, Ghinai I, Pray I, Kimball A, Layer M, Tenforde MW, et al. Pulmonary Illness Related to E-Cigarette Use in Illinois and Wisconsin - Final Report. N Engl J Med 2020; 382: 903-16.
    Pubmed CrossRef
  9. CDC, Outbreak of Lung Injury Associated with the Use of E-Cigarette, or Vaping, Products [internet] Centers for Disease Control and Prevention. [cited 2021 Dec 15]. Available from https://www.cdc.gov/tobacco/basic_information/e-cigarettes/severe-lung-disease.html.
  10. Nair N, Hurley M, Gates S, Davies P, Chen IL, Todd I, et al. Life-threatening hypersensitivity pneumonitis secondary to ecigarettes. Arch Dis Child 2020; 105: 1114-6.
    Pubmed CrossRef
  11. Casanova GS, Amaro R, Soler N, Sanchez M, Badia JR, Barbera JA, et al. An imported case of e-cigarette or vaping associated lung injury in Barcelona. Eur Respir J 2020; 55.
    Pubmed CrossRef
  12. Marliere C, De Greef J, Gohy S, Hoton D, Wallemacq P, Jacquet LM, et al. Fatal e-cigarette or vaping associated lung injury (EVALI): a first case report in Europe. Eur Respir J 2020; 56.
    Pubmed CrossRef
  13. Itoh M, Aoshiba K, Herai Y, Nakamura H, Takemura T. Lung injury associated with electronic cigarettes inhalation diagnosed by transbronchial lung biopsy. Respirol Case Rep 2018; 6: e00282.
    Pubmed KoreaMed CrossRef
  14. Viswam D, Trotter S, Burge PS, Walters GI. Respiratory failure caused by lipoid pneumonia from vaping e-cigarettes. BMJ Case Rep 2018; 2018.
    Pubmed KoreaMed CrossRef
  15. Krishnasamy VP, Hallowell BD, Ko JY, Board A, Hartnett KP, Salvatore PP, et al. Update: Characteristics of a Nationwide Outbreak of E-cigarette, or Vaping, Product Use-Associated Lung Injury - United States, August 2019-January 2020. MMWR Morb Mortal Wkly Rep 2020; 69: 90-4.
    Pubmed KoreaMed CrossRef
  16. Ghinai I, Navon L, Gunn JKL, Duca LM, Brister S, Love S, et al. Characteristics of Persons Who Report Using Only Nicotine-Containing Products Among Interviewed Patients with E-cigarette, or Vaping, Product Use-Associated Lung Injury - Illinois, August-December 2019. MMWR Morb Mortal Wkly Rep 2020; 69: 84-9.
    Pubmed KoreaMed CrossRef
  17. Wang MP, Ho SY, Leung LT, Lam TH. Electronic Cigarette Use and Respiratory Symptoms in Chinese Adolescents in Hong Kong. JAMA Pediatr 2016; 170: 89-91.
    Pubmed CrossRef
  18. McConnell R, Barrington-Trimis JL, Wang K, Urman R, Hong H, Unger J, et al. Electronic Cigarette Use and Respiratory Symptoms in Adolescents. Am J Respir Crit Care Med 2017; 195: 1043-9.
    Pubmed KoreaMed CrossRef
  19. Cho JH, Paik SY. Association between Electronic Cigarette Use and Asthma among High School Students in South Korea. PLoS One 2016; 11: e0151022.
    Pubmed KoreaMed CrossRef
  20. Xie W, Kathuria H, Galiatsatos P, Blaha MJ, Hamburg NM, Robertson RM, et al. Association of Electronic Cigarette Use With Incident Respiratory Conditions Among US Adults From 2013 to 2018. JAMA Netw Open 2020; 3: e2020816.
    Pubmed KoreaMed CrossRef
  21. Wang JB, Olgin JE, Nah G, Vittinghoff E, Cataldo JK, Pletcher MJ, et al. Cigarette and e-cigarette dual use and risk of cardiopulmonary symptoms in the Health eHeart Study. PLoS One 2018; 13: e0198681.
    Pubmed KoreaMed CrossRef
  22. Flacco ME, Fiore M, Acuti Martellucci C, Ferrante M, Gualano MR, Liguori G, et al. Tobacco vs. electronic cigarettes: absence of harm reduction after six years of follow-up. Eur Rev Med Pharmacol Sci 2020; 24: 3923-34.
  23. Polosa R, Morjaria JB, Prosperini U, Busa B, Pennisi A, Malerba M, et al. COPD smokers who switched to e-cigarettes: health outcomes at 5-year follow up. Ther Adv Chronic Dis 2020; 11: 2040622320961617.
    Pubmed KoreaMed CrossRef
  24. Maouche K, Medjber K, Zahm JM, Delavoie F, Terryn C, Coraux C, et al. Contribution of alpha7 nicotinic receptor to airway epithelium dysfunction under nicotine exposure. Proc Natl Acad Sci U S A 2013; 110: 4099-104.
    Pubmed KoreaMed CrossRef
  25. Scott A, Lugg ST, Aldridge K, Lewis KE, Bowden A, Mahida RY, et al. Pro-inflammatory effects of e-cigarette vapour condensate on human alveolar macrophages. Thorax 2018; 73: 1161-9.
    Pubmed KoreaMed CrossRef
  26. Mravec B, Tibensky M, Horvathova L, Babal P. E-Cigarettes and Cancer Risk. Cancer Prev Res (Phila) 2020; 13: 137-44.
    Pubmed CrossRef
  27. Ghosh A, Coakley RC, Mascenik T, Rowell TR, Davis ES, Rogers K, et al. Chronic E-Cigarette Exposure Alters the Human Bronchial Epithelial Proteome. Am J Respir Crit Care Med 2018; 198: 67-76.
    Pubmed KoreaMed CrossRef
  28. Chaumont M, van de Borne P, Bernard A, Van Muylem A, Deprez G, Ullmo J, et al. Fourth generation e-cigarette vaping induces transient lung inflammation and gas exchange disturbances: results from two randomized clinical trials. Am J Physiol Lung Cell Mol Physiol 2019; 316: L705-19.
    Pubmed KoreaMed CrossRef
  29. Sassano MF, Davis ES, Keating JE, Zorn BT, Kochar TK, Wolfgang MC, et al. Evaluation of e-liquid toxicity using an open-source highthroughput screening assay. PLoS Biol 2018; 16: e2003904.
    Pubmed KoreaMed CrossRef
  30. Bozier J, Rutting S, Xenaki D, Peters M, Adcock I, Oliver BG. Heightened response to e-cigarettes in COPD. ERJ Open Res 2019; 5: 00192-2018.
    Pubmed KoreaMed CrossRef
  31. Hartmann-Boyce J, McRobbie H, Butler AR, Lindson N, Bullen C, Begh R, et al. Electronic cigarettes for smoking cessation. Cochrane Database Syst Rev 2021; 9: CD010216.
    Pubmed CrossRef
  32. Hajek P, Phillips-Waller A, Przulj D, Pesola F, Myers Smith K, Bisal N, et al. A Randomized Trial of E-Cigarettes versus Nicotine-Replacement Therapy. N Engl J Med 2019; 380: 629-37.
    Pubmed CrossRef
  33. Anthenelli RM, Benowitz NL, West R, St Aubin L, McRae T, Lawrence D, et al. Neuropsychiatric safety and efficacy of varenicline, bupropion, and nicotine patch in smokers with and without psychiatric disorders (EAGLES): a double-blind, randomised, placebo-controlled clinical trial. The Lancet 2016; 387: 2507-20.
    CrossRef