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Association between Types of Tobacco Products and Allergic Diseases: The Korea Youth Risk Behavior Survey 2019
J Korean Soc Res Nicotine Tob 2020; 11(2): 48-55
Published online December 15, 2020
© 2020 The Korean Society for Research on Nicotine and Tobacco.

Yea Na Shin, Hong Jun Cho*

Department of Family Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
Correspondence to: 조홍준
울산대학교 의과대학 서울아산병원 가정의학과
E-mail: hjcho@amc.seoul.kr
ORCID: https://orcid.org/0000-0002-5358-6549
Received September 16, 2020; Revised October 12, 2020; Accepted October 12, 2020.
This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, dis-tribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
Background: The relationship between the types of tobacco products and allergic diseases remains unclear. Hence, this study determined whether the current use of tobacco and combination of cigarettes, such as conventional cigarettes (CC), electronic cigarettes (EC), and heated tobacco products (HTP), among Korean adolescents affects the development of allergic diseases.
Methods: This cross-sectional study analyzed the data from the 15th Korean Youth Risk Behavior survey. Participants included 55,748 adolescents at the age of 13-18 years. We performed a multivariable logistic regression analysis and calculated odds ratios (ORs) and 95% confidence interval (CI) of having allergic diseases.
Results: Asthma, allergic rhinitis, and atopic dermatitis were reported by 1.5%, 20.0%, and 6.4% of the total participants, respectively. The rates of allergic diseases were the highest in EC and HTP users together. After adjusting for confounding variables, adolescents who used only HTP were associated with the highest risks of having asthma (OR, 6.80; 95% CI, 2.28-20.32) and atopic dermatitis (OR, 2.73; 95% CI, 1.11-6.76) compared with those who never used tobacco. Among adolescents who used EC and HTP together, the ORs of allergic rhinitis were the highest (OR, 1.79; 95% CI, 1.04-3.09).
Conclusion: The association with increased allergic diseases was relevant in adolescents who smoked, especially those who used combustible cigarette alternatives. We should be vigilant of the use of HTP, CC, and EC, the hazards of which are already known among adolescents.
Keywords : Asthma; Allergic dermatitis; Atopic dermatitis; Electronic cigarettes; Heated tobacco products; Korean adolescents
References
  1. Baiardini I, Braido F, Brandi S, Canonica GW. Allergic diseases and their impact on quality of life. Annals of Allergy, Asthma & Immunology 2006; 97: 419-29.
    CrossRef
  2. GGA N. The Global Asthma Report 2018. 2018.
  3. Pawankar R, Canonica G, Holgate S, Lockey R, Blaiss M. WAO white book on allergy: update 2013. World Allergy Organization 2013; 248.
  4. DaVeiga SP. Epidemiology of atopic dermatitis: a review. Allergy &Asthma Proceedings; 2012; 33(3): 227-34.
    Pubmed CrossRef
  5. Population projections for Korea (2015-2065). Statistics Korea:Daejeon, Korea. 2016.
  6. kosis.kr[internet]. Korea: Statistics of Health Insurance Corporation;c2018 [cited 2020 Sep 10].
    Available from: http://kosis.kr
  7. Ahn HS. Pediatrics, 10th ed. Seoul. MiraeN Press 2012; p1110-1119.
  8. Burgess JA, Walters EH, Byrnes GB, Matheson MC, Jenkins MA, Wharton CL, et al. Childhood allergic rhinitis predicts asthma incidence and persistence to middle age: a longitudinal study. Journal of Allergy and Clinical Immunology 2007; 120: 863-9.
    Pubmed CrossRef
  9. Margolis JS, Abuabara K, Bilker W, Hoffstad O, Margolis DJ. Persistence of mild to moderate atopic dermatitis. JAMA dermatology 2014; 150: 593-600.
    Pubmed KoreaMed CrossRef
  10. Akinbami LJ, Schoendorf KC. Trends in childhood asthma: prevalence, health care utilization, and mortality. Pediatrics 2002; 110: 315-22.
    Pubmed CrossRef
  11. Coogan PF, Castro-Webb N, Yu J, O’Connor GT, Palmer JR, Rosenberg L. Active and passive smoking and the incidence of asthma in the Black Women’s Health Study. American journal of respiratory and critical care medicine 2015; 191: 168-76.
    Pubmed KoreaMed CrossRef
  12. Saulyte J, Regueira C, Montes-Martínez A, Khudyakov P, Takkouche B. Active or passive exposure to tobacco smoking and allergic rhinitis, allergic dermatitis, and food allergy in adults and children: a systematic review and meta-analysis. PLoS medicine 2014; 11(3): e1001611.
    Pubmed KoreaMed CrossRef
  13. Fowles J, Dybing E. Application of toxicological risk assessment principles to the chemical constituents of cigarette smoke. Tobacco control 2003; 12: 424-30.
    Pubmed KoreaMed CrossRef
  14. Strzelak A, Ratajczak A, Adamiec A, Feleszko W. Tobacco smoke induces and alters immune responses in the lung triggering inflammation, allergy, asthma and other lung diseases: a mechanistic review. International journal of environmental research and public health 2018;15: 1033.
    Pubmed KoreaMed CrossRef
  15. Botelho FM, Llop-Guevara A, Trimble NJ, Nikota JK, Bauer CM, Lambert KN, et al. Cigarette smoke differentially affects eosinophilia and remodeling in a model of house dust mite asthma. American journal of respiratory cell and molecular biology 2011; 45: 753-60.
    Pubmed CrossRef
  16. Martin EM, Clapp PW, Rebuli ME, Pawlak EA, Glista-Baker E, Benowitz NL, et al. E-cigarette use results in suppression of immune and inflammatory-response genes in nasal epithelial cells similar to cigarette smoke. American Journal of Physiology-Lung Cellular and Molecular Physiology 2016; 311: L135-L44.
    Pubmed KoreaMed CrossRef
  17. Karthik L, Kumar G, Keswani T, Bhattacharyya A, Chandar SS, Rao KB. Protease inhibitors from marine actinobacteria as a potential source for antimalarial compound. PloS one 2014; 9(3): e90972.
    Pubmed KoreaMed CrossRef
  18. Sohal SS, Eapen MS, Naidu VG, Sharma P. IQOS exposure impairs human airway cell homeostasis: direct comparison with traditional cigarette and e-cigarette. ERJ open research 2019; 5(1): 00159-2018.
    Pubmed KoreaMed CrossRef
  19. Korea Centers for Disease Control and prevention. Major finding from KNHANES (2018) and KYRBSS (2019). Cheongju: Korea Centers for Disease Control and Prevention; 2019.
  20. Kang SY, Lee S, Cho H-J. Prevalence and predictors of heated tobacco product use and its relationship with attempts to quit cigarette smoking among Korean adolescents. Tobacco Control. 2020 Feb. DOI: 10.1136/tobaccocontrol-2019-055114.
    Pubmed CrossRef
  21. KOSIS. Korea Youth Risk Behavior Web-based Survey [Internet]. Seoul 2019. [cited 2020 Sep 10].
    Available from: http://kosis.kr
  22. Lee JA, Lee S, Cho H-J. The relation between frequency of e-cigarette use and frequency and intensity of cigarette smoking among South Korean adolescents. International journal of environmental research and public health 2017; 14: 305.
    Pubmed KoreaMed CrossRef
  23. Lee A, Lee SY, Lee K-S. The Use of Heated Tobacco Products is Associated with Asthma, Allergic Rhinitis, and Atopic Dermatitis in Korean Adolescents. Scientific reports 2019; 9: 1-8.
    Pubmed KoreaMed CrossRef
  24. Chung SJ, Kim BK, Oh JH, Shim JS, Chang YS, Cho SH, et al. Novel tobacco products including electronic cigarette and heated tobacco products increase risk of allergic rhinitis and asthma in adolescents:Analysis of Korean youth survey. Allergy 2020; 75(7): 1640-8.
    Pubmed CrossRef
  25. Stämpfli MR, Anderson GP. How cigarette smoke skews immune responses to promote infection, lung disease and cancer. Nature Reviews Immunology 2009; 9: 377-84.
    Pubmed CrossRef
  26. Leigh NJ, Tran PL, O’Connor RJ, Goniewicz ML. Cytotoxic effects of heated tobacco products (HTP) on human bronchial epithelial cells. Tobacco control 2018; 27: s26-s9.
    Pubmed KoreaMed CrossRef
  27. Farsalinos KE, Yannovits N, Sarri T, Voudris V, Poulas K, Leischow SJ. Carbonyl emissions from a novel heated tobacco product (IQOS):comparison with an e‐cigarette and a tobacco cigarette. Addiction 2018; 113: 2099-106.
    Pubmed CrossRef
  28. Starkenburg S, Munroe ME, Waltenbaugh C. Early alteration in leukocyte populations and Th1/Th2 function in ethanol-consuming mice. Alcohol Clin Exp Res 2011; 25: 1221-30.
    CrossRef
  29. Farfel A, Tirosh A, Derazne E, Garty BZ, Afek A. Association between socioeconomic status and the prevalence of asthma. Ann Allergy Asthma Immunol 2010; 104: 490-5.
    Pubmed CrossRef
  30. Hersoug LG, Linneberg A. The link between the epidemics of obesity and allergic disease: does obesity induce decreased immune tolerance? Allergy 2007; 62: 1205-13.
    Pubmed CrossRef