search for



Crossref

Cross mark

Cited-by

Fundref

TDM

Correlation of past smoking behaviors and duration of smoking cessation with high-sensitivity C-reactive protein among past smokers in Korean male adults : Korean National Health and Nutrition Examination Survey.
J Korean Soc Res Nicotine Tob
Published online October 5, 2018
© 2018 The Korean Society for Research on Nicotine and Tobacco.

Yong Ho Sohn 1, Sang-keun Hahm 1, *, Jin-ah Park 1, Min Woo Shin 1, Eun-hye Yoo 1, Seung-joo Lee 1, Min-seok Oh 1, Ji-yeong Jung 1, Jae-hyung Rhim 1

Department of Family Medicine, Hanil General Hospital
Correspondence to: Sang-keun Hahm, 꽌슱 룄遊됯뎄 슦씠泥쒕줈 308 븳씪蹂묒썝 媛젙쓽븰怨, 슦렪踰덊샇: 01450, 쟾솕: 09-901-3169, 뙥뒪: 02-901-3164, 씠硫붿씪: 03580212@hanilmed.net
 Abstract
Introduction
C-reactive protein (CRP) can be used to assess the risk of cardiovascular disease. Previous studies have demonstrated the relationship between cigarette smoking and high-sensitivity CRP (hs-CRP) elevation. However, the effects of smoking cessation on hs-CRP have not been evaluated in Korean male adults.
Methods
Based on the Korean National Health and Nutrition Examination Survey of 2015~2016, self-reported former smokers were selected. Participants with laboratory test results suggesting acute inflammation or any history of conditions that could elevate CRP levels were excluded. The frequency of hs-CRP elevation was compared between groups with various past smoking behaviors and duration of smoking cessation.
Results
The total number of selected participants was 1,243. Participants with larger cumulative smoking amount (P=0.026) or shorter duration of smoking cessation (P=0.024) tended to have significantly higher frequency of hs-CRP elevation. By logistic regression analysis, larger cumulative smoking amount have shown higher probability of hs-CRP elevation than smaller amount, but with no statistical significance. Long-term (>10years) and mid-term (5~10years) cessation have shown lower probability of hs-CRP elevation than short-term (<5years), with statistical significance only between short-term and long-term cessation (odds ratio 0.64; 95% confidence interval 0.41-0.98, P=0.038).
Conclusion
Among past smokers in Korean male adults, the frequency of hs-CRP level elevation tended to be higher with larger cumulative smoking amount or shorter duration of smoking cessation. The risk of hs-CRP elevation was significantly lower with long-term smoking cessation than short-term cessation.
Keywords : Smoking cessation, C-reactive protein, Cardiovascular disease, KNHANES